BIOL 1010 OR BIOL 1031 OR BIOA 1002 OR SCIE 1505
Analyze human pedigrees to determine if a trait is dominant or recessive, if the gene for the trait is located on an autosome or sex chromosome, and if the trait is likely controlled by a single gene or more than one gene. [BIOL 1010] Compare and contrast the fundamental features of mitosis and meiosis with emphasis on the movement of homologous chromosomes during these cellular reproductive processes [BIOL 1010] [BIOL 1030] Define gene flow and genetic drift (and founder effect) and explain how they influence allele frequencies in populations [BIOL 1010] Define Mendel’s two laws of heredity that explain the transmission of traits from one generation to the next [BIOL 1010] [BIOL 1030] Define the classes of physical and chemical mutagens and their effect on the coded amino acids in a polypeptide, and the resulting phenotype [BIOL 1010] Describe the basic chemical structure of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), and their function in the processes of replication, transcription, and translation of genetic information. [BIOL 1010] [BIOL 1030] Describe the basic structure and function of organelles [BIOL 1010] [BIOL 1030] Describe the components of a formal laboratory report Describe the most basic similarities and differences between Bacteria, Archaea and Eukaryotes, and the evolutionary relationships between ‘protists’ and animals, plants and fungi. [BIOL 1010] Identify the regulatory elements and how they function in the control of gene expression of inducible and repressible operons in prokaryotes [BIOL 1010] [BIOL 1030] Recall the steps relating to cell division [BIOL 1010] Understand the basic principles of DNA technology/Biotechnology, its applications and the ethical and societal implications of this technological revolution [BIOL 1010] [BIOL 1030] Write a properly formatted CSE-style (Council of Science Editors) citation for a website, article or book; quote from and/or cite published material as appropriate; read an article from a scientific journal and discuss its content with classmates. [BIOL 1010] [BIOL 1011] Describe the different macromolecules [BIOL 1010] [BIOL 1030] Use the Hardy-Weinberg principle to calculate expected genotype and allele frequencies (1 Locus, 2 Alleles) [BIOL 1010] Express the concepts of evolution as changes in allele frequencies and the Hardy-Weinberg principle.
Develop a basic understanding and appreciation of techniques used in genetic and molecular biology laboratories.Explain and illustrate the fundamental biochemistry required in the application of modern techniques of molecular biology: (i) screen complementary (cDNA) and genomic libraries to identify and clone specific DNA (gene) sequences; (ii) DNA sequencingGenerate and interpret data collected from experiments in the laboratory and communicate results by a variety of written forms.Access the Faculty of Science Academic Integrity Module in order to be able to elaborate on Dalhousie’s policies on academic integrity and the penalties that relate to plagiarism.Apply knowledge of genetics to the analysis of human pedigrees.Compare and contrast the fundamental mechanisms that regulate gene expression in prokaryotic and eukaryotic cells.Define in detail the classes of physical and chemical mutagens, how a chemical mutagen can be identified by the Ames test, and the effect of different types of mutation on phenotype.Demonstrate ability to properly summarize, paraphrase, cite and reference scientific literature in order to avoid plagiarism.Describe and diagram the structure of DNA.Describe how DNA is transcribed to RNA and how RNA is translated into proteins.Describe in detail restriction endonucleases, their recognition sequences in DNA, and their application in the Southern blot and hybridization technique for diagnosis of human genetic disease.Describe the structure of RNA and understand how post-transcriptional processing modifies it prior to translation.Diagram chromosome structure, the types of rearrangements and explain the consequences of variations in chromosomal number.Explain and illustrate how DNA replication and recombinationInterpret genetic and protein variability using detailed knowledge of the genetic code and the processes of transcription and translation.Recognize the importance of genetics to society and the study of biology, and be able to effectively explain this to non-specialists.Apply the Mendelian principles of heredity for both autosomal and sex-linked inheritance.Comprehend the basic principles of population and quantitative genetics, and give examples of their application to real biological systems.Explain how complex genetic systems lead to modifications of the basic principles of Mendelian inheritance.Interpret Mendel’s rules of heredity in terms of the eukaryotic cell cycle. Describe meitoic crossing over and its relationship to genetic linkage.Apply theories and topics learned in the course by solving problems in lecture, tutorials and labs.
